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عمومی::
شرایط پاتولوژیک
Looking forward, the in- herent plasticity of macrophages represents a daunting challenge for harnessing these cells in regenerative med- icine therapies but also great opportunity for improving patient outcomes in a variety of pathological conditions.
Indeed, insufficient accumulation of either M1-like macrophages at early stages of tissue repair [31-33] or of M2-like macrophages at later stages [17,32] both have been associated with ineffective healing characteristic of pathologic conditions like diabetic wounds.
geous even in pathological conditions that suffer from impaired macro- phage infiltration.
Better understanding of the context-depen- dent macrophage functions and the myriad factors that regulate macro- phage phenotype along with rigorous quality control measures will provide great opportunity for improving patient outcomes in a variety of pathological conditions.
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